Introduction – Company Background
GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.
With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.
With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.
From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.
At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.
By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.
Core Strengths in Insole Manufacturing
At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.
Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.
We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.
With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.
Customization & OEM/ODM Flexibility
GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.
Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.
With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.
Quality Assurance & Certifications
Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.
We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.
Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.
ESG-Oriented Sustainable Production
At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.
To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.
We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.
Let’s Build Your Next Insole Success Together
Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.
From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.
Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.
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Thailand ODM expert for comfort products
Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.
With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Graphene cushion OEM factory in Indonesia
Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.
We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.High-performance graphene insole OEM Indonesia
At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Eco-friendly pillow OEM manufacturer China
📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Memory foam pillow OEM factory Thailand
University of Michigan researchers have discovered the protein GluK2 as the key to how mammals sense cold, a finding that could impact treatments for conditions like the cold sensitivity experienced by chemotherapy patients. Researchers at the University of Michigan have discovered the protein that enables mammals to sense cold, filling a long-standing knowledge gap in the field of sensory biology. The findings, published in Nature Neuroscience, could help unravel how we sense and suffer from cold temperature in the winter, and why some patients experience cold differently under particular disease conditions. “The field started uncovering these temperature sensors over 20 years ago, with the discovery of a heat-sensing protein called TRPV1,” said neuroscientist Shawn Xu, a professor at the U-M Life Sciences Institute and a senior author of the new research. “Various studies have found the proteins that sense hot, warm, even cool temperatures—but we’ve been unable to confirm what senses temperatures below about 60 degrees Fahrenheit.” In a2019 study, researchers in Xu’s lab discovered the first cold-sensing receptor protein in Caenorhabditis elegans, a species of millimeter-long worms that the lab studies as a model system for understanding sensory responses. Because the gene that encodes the C. elegans protein is evolutionarily conserved across many species, including mice and humans, that finding provided a starting point for verifying the cold sensor in mammals: a protein called GluK2 (short for Glutamate ionotropic receptor kainate type subunit 2). Identifying the Mammalian Cold Sensor For this latest study, a team of researchers from the Life Sciences Institute and the U-M College of Literature, Science, and the Arts tested their hypothesis in mice that were missing the GluK2 gene, and thus could not produce any GluK2 proteins. Through a series of experiments to test the animals’ behavioral reactions to temperature and other mechanical stimuli, the team found that the mice responded normally to hot, warm, and cool temperatures, but showed no response to noxious cold. GluK2 is primarily found on neurons in the brain, where it receives chemical signals to facilitate communication between neurons. But it is also expressed in sensory neurons in the peripheral nervous system (outside the brain and spinal cord). “We now know that this protein serves a totally different function in the peripheral nervous system, processing temperature cues instead of chemical signals to sense cold,” said Bo Duan, U-M associate professor of molecular, cellular, and developmental biology and co-senior author of the study. While GluK2 is best known for its role in the brain, Xu speculates that this temperature-sensing role may have been one of the protein’s original purposes. The GluK2 gene has relatives across the evolutionary tree, going all the way back to single-cell bacteria.”A bacterium has no brain, so why would it evolve a way to receive chemical signals from other neurons? But it would have great need to sense its environment, and perhaps both temperature and chemicals,” said Xu, who is also a professor of molecular and integrative physiology at the U-M Medical School. “So I think temperature sensing may be an ancient function, at least for some of these glutamate receptors, that was eventually co-opted as organisms evolved more complex nervous systems.” In addition to filling a gap in the temperature-sensing puzzle, Xu believes the new finding could have implications for human health and well-being. Cancer patients receiving chemotherapy, for example, often experience painful reactions to cold. “This discovery of GluK2 as a cold sensor in mammals opens new paths to better understand why humans experience painful reactions to cold, and even perhaps offers a potential therapeutic target for treating that pain in patients whose cold sensation is overstimulated,” Xu said. Reference: “The kainate receptor GluK2 mediates cold sensing in mice” by Wei Cai, Wenwen Zhang, Qin Zheng, Chia Chun Hor, Tong Pan, Mahar Fatima, Xinzhong Dong, Bo Duan and X. Z. Shawn Xu, 11 March 2024, Nature Neuroscience. DOI: 10.1038/s41593-024-01585-8 The research was supported by the National Institutes of Health. All procedures performed in mice were approved by the Institutional Animal Care and Use Committee and performed in accordance with the institutional guidelines.
A study by researchers from the Medical Research Council and Imperial College London showed that inhibiting the protein IL-11 in mice can increase their lifespan by up to 25%. The treatment reduced aging signs and cancer rates, suggesting potential applications in human aging, with clinical trials already underway. Credit: SciTechDaily Inhibiting IL-11 in mice extends lifespan and reduces aging signs, with potential implications for human aging treatments. Researchers from the Medical Research Council Laboratory of Medical Science and Imperial College London have discovered that ‘switching off’ a protein called IL-11 can increase the healthy lifespan of mice by nearly 25%. Working alongside colleagues at Duke-NUS Medical School in Singapore, they tested the effects of IL-11 by creating mice that had the gene-producing IL-11 (interleukin 11) deleted, which extended the lives of the mice by over 20% on average. Additionally, they treated 75-week-old mice – equivalent to the age of about 55 years in humans – with an injection of an anti-IL-11 antibody, a drug that stops the effects of IL-11 in the body. Promising Results with Anti-IL-11 Treatment In their study, recently published in Nature, the researchers found that treatment with the anti-IL-11 drug from 75 weeks of age until death extended the median lifespan of male mice by 22.5% and of female mice by 25%. The treated mice lived for an average of 155 weeks, whereas the untreated mice lived for an average of 120 weeks. The treatment largely reduced deaths from cancer in the animals, as well as reducing the many diseases caused by fibrosis, chronic inflammation, and poor metabolism, which are hallmarks of aging. There were very few side effects observed. Video showing the knockout mice that do not produce IL-11 on the left, and normally aging mice on the right, at 90-95 weeks old. Credit: MRC Laboratory of Medical Science / Duke-NUS Medical School “These findings are very exciting. The treated mice had fewer cancers, and were free from the usual signs of aging and frailty, but we also saw reduced muscle wasting and improvement in muscle strength. In other words, the old mice receiving anti-IL11 were healthier,” said co-corresponding author Professor Stuart Cook from the Medical Research Council Laboratory of Medical Science (MRC LMS), Imperial College London, and Duke-NUS Medical School in Singapore. “Previously proposed life-extending drugs and treatments have either had poor side-effect profiles, or don’t work in both sexes, or could extend life, but not healthy life, however this does not appear to be the case for IL-11.” “While these findings are only in mice, it raises the tantalizing possibility that the drugs could have a similar effect in elderly humans. Anti-IL-11 treatments are currently in human clinical trials for other conditions, potentially providing exciting opportunities to study its effects in aging humans in the future.” Historical and Future Perspectives on IL-11 Research The researchers have been investigating IL-11 for many years and in 2018 they were the first to show that IL-11 is a pro-fibrotic and pro-inflammatory protein, overturning years of incorrect characterization as anti-fibrotic and anti-inflammatory. Assistant Professor Anissa Widjaja from Duke-NUS Medical School, Singapore, who was a co-corresponding author, said: “This project started back in 2017 when a collaborator of ours sent us some tissue samples for another project. Out of curiosity, I ran some experiments to check for IL-11 levels. From the readings, we could clearly see that the levels of IL-11 increased with age and that’s when we got really excited!” Professor Stuart Cook. Credit: MRC Laboratory of Medical Science “We found these rising levels contribute to negative effects in the body, such as inflammation and preventing organs from healing and regenerating after injury. Although our work was done in mice, we hope that these findings will be highly relevant to human health, given that we have seen similar effects in studies of human cells and tissues. “This research is an important step toward better understanding aging and we have demonstrated, in mice, a therapy that could potentially extend healthy aging, by reducing frailty and the physiological manifestations of aging.” Addressing Global Health Challenges with New Insights Previously, scientists have posited that IL-11 is an evolutionary hangover in humans, as while it is vital for limb regeneration in some animal species, it is thought to be largely redundant in humans. However, after about the age of 55 in humans, more IL-11 is produced and past research has linked this to chronic inflammation, fibrosis in organs, disorders of metabolism, muscle wasting (sarcopaenia), frailty, and cardiac fibrosis. These conditions are many of the signs we associate with aging. When two or more such conditions occur in an individual, it is known as multimorbidity, which encompasses a range of conditions including lung disease, cardiovascular disease, diabetes, vision and hearing decline, and a host of other conditions. “The IL-11 gene activity increases in all tissues in the mouse with age. When it gets turned on it causes multimorbidity, which is diseases of aging and loss of function across the whole body, ranging from eyesight to hearing, from muscle to hair, and from the pump function of the heart to the kidneys,” said Cook. Multimorbidity and frailty are acknowledged to be among the biggest global healthcare challenges of the 21st century, according to many leading health bodies, including the NHS, and WHO. Currently, no treatment for multimorbidity is available, other than to try to treat the separate multiple underlying causes individually. The scientists caution that the results in this study were in mice and the safety and effectiveness of these treatments in humans need further establishment in clinical trials before people consider using anti-IL-11 drugs for this purpose. Reference: “Inhibition of IL-11 signalling extends mammalian healthspan and lifespan” by Anissa A. Widjaja, Wei-Wen Lim, Sivakumar Viswanathan, Sonia Chothani, Ben Corden, Cibi Mary Dasan, Joyce Wei Ting Goh, Radiance Lim, Brijesh K. Singh, Jessie Tan, Chee Jian Pua, Sze Yun Lim, Eleonora Adami, Sebastian Schafer, Benjamin L. George, Mark Sweeney, Chen Xie, Madhulika Tripathi, Natalie A. Sims, Norbert Hübner, Enrico Petretto, Dominic J. Withers, Lena Ho, Jesus Gil, David Carling and Stuart A. Cook, 17 July 2024, Nature. DOI: 10.1038/s41586-024-07701-9 The study was primarily funded by the National Medical Research Council (Singapore), and the Medical Research Council (UK).
Newly described Schneider’s marmoset. Credit: Rodrigo Costa-Araújo “Schneider’s marmoset” is found in the highly threatened, but little-studied forests of Mato Grosso State. team of scientists has discovered a new marmoset species in the Brazilian Amazon. Schneider’s marmoset (Mico schneideri), described in the latest issue of the journal Scientific Reports, is named after professor Horacio Schneider, a pioneer and major contributor to the research of diversity and evolution of monkeys. The discovery was made by a team of researchers led by Rodrigo Costa Araújo, currently an associate researcher at Museu Paraense Emílio Goeldi. Araújo was funded in part by the Conservation Leadership Programme (CLP), a capacity-building partnership between WCS, BirdLife International and Fauna & Flora International (FFI). The Amazon marmosets of the genus Mico are among the more diverse groups of monkeys and found only in the threatened forests of the “arc of deforestation,” a region that accounts for half of the global land use change in the past 30 years. Currently, there is no conservation response to address the losses of habitat and population decreases such marmosets are subjected to, primarily because they are poorly studied. The total number of Amazon marmoset species remains unknown. In 2019 Araújo and his team discovered the Munduruku marmoset (Mico munduruku) from another area within the arc of deforestation. M. schneideri was described from marmosets known to researchers since 1995 but misidentified as M. emiliae. The study notes the existence of 16 Mico species located in the “arc of deforestation” – an extensive region in the southern Amazon where the highest rates of land clearing and fires are concentrated. Further research is needed to assess the conservation status of M. schneideri and to investigate the southern portion of its geographical distribution. Additionally, continuing to uncover exactly how many Amazon marmosets occupy these forests will underpin the first step towards conserving this threatened group of monkeys. Reference: “An integrative analysis uncovers a new, pseudo-cryptic species of Amazonian marmoset (Primates: Callitrichidae: Mico) from the arc of deforestation” by Rodrigo Costa-Araújo, José S. Silva-Jr., Jean P. Boubli, Rogério V. Rossi, Gustavo R. Canale, Fabiano R. Melo, Fabrício Bertuol, Felipe E. Silva, Diego A. Silva, Stephen D. Nash, Iracilda Sampaio, Izeni P. Farias and Tomas Hrbek, 2 August 2021, Scientific Reports. DOI: 10.1038/s41598-021-93943-w The research was possible due to a scholarship provided by CNPq and funding provided by CAPES, FAPESP, FAPEMAT, Conservation Leadership Programme, Primate Action Fund Re:Wild, National Science Foundation, NERC and Idea Wild.
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